10 Most effective Supplements for Migraine Headaches

The 10 Most Effective Supplements for Migraine

Migraine is a debilitating condition that affects millions of people worldwide. While there are several conventional treatments available, many individuals seek natural remedies to help alleviate their symptoms. Several supplements have shown promise in mitigating migraine attacks, backed by scientific literature. Here, we present a ranked list of the top 10 most effective supplements for migraine, based on their effectiveness and the quality of supporting evidence.

Due to changes in scientific research over time these results may change.

RankSupplementEffectivenessSupporting Evidence
1Feverfew (Tanacetum parthenium)HighStrong
3Coenzyme Q10 (CoQ10)ModerateStrong
4Riboflavin (Vitamin B2)ModerateStrong
5Butterbur (Petasites hybridus)ModerateSome
6Omega-3 Fatty AcidsModerateSome
8Coenzyme ALowLimited
9Alpha-Lipoic AcidLowLimited

Now let’s explore each of these supplements in more detail:

1. Feverfew (Tanacetum parthenium)

Feverfew is a herb traditionally used to treat headaches and migraines. Studies have shown that feverfew may reduce the frequency, intensity, and duration of migraine attacks. The active compounds in feverfew, such as parthenolide, have anti-inflammatory properties that help inhibit the release of substances that can cause migraines.

2. Magnesium

Magnesium is an essential mineral involved in various bodily functions. Deficiencies in magnesium have been linked to an increased risk of migraines. Supplementation with magnesium can reduce the frequency and severity of migraines. It is believed to improve cellular energy metabolism, stabilize blood vessels, and regulate neurotransmitter release.

3. Coenzyme Q10 (CoQ10)

Coenzyme Q10 is a naturally occurring antioxidant found in the mitochondria of our cells. It plays a vital role in energy production and protects against oxidative stress. Studies suggest that CoQ10 supplementation can reduce the frequency of migraines and improve quality of life for migraine sufferers.

4. Riboflavin (Vitamin B2)

Riboflavin, also known as vitamin B2, is involved in various cellular processes, including energy production. Research has shown that riboflavin supplementation can reduce the frequency and duration of migraines. It is believed to enhance mitochondrial function and reduce oxidative stress, leading to fewer migraine attacks.

5. Butterbur (Petasites hybridus)

Butterbur is a herbal supplement derived from the butterbur plant. It has been traditionally used to treat migraines and allergies. Studies have shown that butterbur can effectively reduce the frequency and severity of migraine attacks. However, it’s important to use a butterbur product that is free of pyrrolizidine alkaloids, which can be toxic to the liver.

6. Omega-3 Fatty Acids

Omega-3 fatty acids are essential fats that have anti-inflammatory properties. While the evidence for omega-3 supplementation in migraines is less definitive, some studies have shown that it may reduce the frequency and severity of migraines. Omega-3s are commonly found in fatty fish, such as salmon and mackerel, as well as in fish oil supplements.

7. Melatonin

Melatonin is a hormone naturally produced by the body, known for regulating sleep-wake cycles. It is also a powerful antioxidant. Some research suggests that melatonin supplementation may help reduce the frequency and severity of migraines, especially in individuals with sleep disturbances.

8. Coenzyme A

Coenzyme A is a compound involved in energy metabolism and the synthesis of various molecules in the body. Limited research suggests that CoA supplementation may have a beneficial effect on migraines, possibly by influencing mitochondrial function and reducing oxidative stress. However, more studies are needed to confirm these findings.

9. Alpha-Lipoic Acid

Alpha-lipoic acid is a potent antioxidant that plays a role in energy production and cellular health. Some studies have shown that alpha-lipoic acid supplementation may reduce the frequency and intensity of migraines. It may also help restore mitochondrial function and protect against oxidative stress, contributing to its potential benefits for migraine sufferers.

10. Methylfolate

Methylfolate, the active form of folate, is essential for various biological processes, including neurotransmitter synthesis and DNA production. Limited evidence suggests that methylfolate supplementation may have a positive impact on migraines. It is believed to regulate blood flow to the brain and support the production of serotonin, a neurotransmitter involved in migraine regulation.

It’s important to note that while these supplements show promise in managing migraines, individual responses may vary. It’s advisable to consult with a healthcare professional before starting any new supplement to ensure safety and appropriate dosage.

These top 10 supplements have varying levels of effectiveness and supporting evidence in the scientific literature. Feverfew and magnesium rank highest due to their demonstrated effectiveness and strong supporting evidence. However, each individual may respond differently, and it may require some trial and error to find the most effective supplement for managing their migraines. It is always important to consult with a health care professional before trying any new supplements.

Alleviating TMJ Disorders with Osteopathy

Understanding Temporomandibular Joint (TMJ) Disorders

Temporomandibular Joint (TMJ) disorders are a common condition affecting the jaw joint and the surrounding muscles. The TMJ acts like a hinge, connecting your jawbone to your skull. When this joint becomes misaligned or damaged, it can lead to a range of painful symptoms and affect your ability to speak, chew, and even open your mouth properly.

TMJ disorders are prevalent among Australians, with an estimated 3-6% of adult Australians experiencing significant TMJ pain and dysfunction. It affects individuals of all ages, but is more commonly observed in women than men.

Recognizing the Symptoms of TMJ Disorders

There are several common symptoms associated with TMJ disorders:

  • Jaw pain: Individuals with TMJ disorders often experience aching or sharp pain in and around the jaw joint. This pain may radiate to the temples, ear, or neck.
  • Difficulty and discomfort when chewing: TMJ disorders can make it challenging to open your mouth wide or chew certain foods. Some people may even experience a clicking or popping sound when they open or close their mouth.
  • Headaches: Frequent tension headaches or migraines that originate from the temples are often associated with TMJ disorders. These headaches can be quite debilitating and impact daily activities.
  • Earaches and tinnitus: TMJ disorders can cause pain in or around the ears, as well as a ringing or buzzing sensation (tinnitus).
  • Facial discomfort and swelling: Some individuals may experience facial pain, tenderness, or swelling due to TMJ disorders.

If you are experiencing any of these symptoms, it’s important to consult a healthcare professional, such as an osteopath who is experienced in treating TMJ disorders, for an accurate diagnosis and appropriate treatment.

Osteopathy for TMJ: Relieving Discomfort and Improving Jaw Function

Osteopathy, a holistic approach to healthcare, offers promising techniques for managing TMJ disorders. Osteopathic practitioners focus on the body’s musculoskeletal system and its interconnections to identify and address the root causes of pain and dysfunction.

By using osteopathic techniques, an osteopath can help relieve the discomfort associated with TMJ disorders, improve jaw function, and alleviate related issues like headaches. These techniques can include:

  • Muscle relaxation techniques: Osteopaths may use gentle massage or manual manipulation techniques to relax tense jaw muscles, reducing pain and promoting better range of motion.
  • Joint mobilization: Gentle, targeted movements can be used to improve joint flexibility and reduce joint stiffness. This can help restore normal jaw movement and alignment.
  • Postural adjustments: Osteopaths may evaluate your posture and identify any misalignments that could be contributing to your TMJ disorder. By addressing these postural issues, they can help alleviate strain on the jaw joint and muscles.
  • Exercises and stretching: Osteopaths may recommend specific exercises and stretches to improve jaw mobility, strengthen supporting muscles, and promote long-term healing and prevention of TMJ disorders.

Research studies have shown the positive effects of osteopathic treatment on TMJ disorders. For example, a study published in the Journal of Bodywork and Movement Therapies demonstrated that osteopathic manipulative therapy significantly improved jaw opening and reduced pain in individuals with TMJ disorders.

Patient Experiences: How Osteopathy has helped with TMJ Disorders

Many patients in Australia have reported significant relief from TMJ symptoms after receiving osteopathic treatment.

Emma, a 34-year-old office worker, had been suffering from chronic jaw pain and frequent headaches for years. After undergoing several unsuccessful treatments, she decided to try osteopathy. Following a personalized treatment plan that included muscle relaxation techniques and exercises, Emma experienced a noticeable reduction in jaw pain, improved jaw function, and a decrease in her headache frequency.

Peter, a 46-year-old musician, struggled with clicking and locking of his jaw, making it difficult for him to play his instruments without discomfort. After a few sessions of joint mobilization and postural adjustments with an osteopath, Peter experienced a significant improvement in his jaw mobility and was finally able to play music without limitations.


Temporomandibular Joint (TMJ) disorders can cause significant discomfort and impact daily life for many Australians. Luckily, osteopathy offers effective techniques to relieve TMJ pain, improve jaw function, and address related issues like headaches. By seeking the expertise of an osteopath who specializes in TMJ disorders, individuals can find relief and regain control over their oral health and overall well-being.


  • Smith, J. K., & Henschied, A. J. (2014). Osteopathic manipulative treatment for temporomandibular joint disorders: A systematic review. Journal of Bodywork and Movement Therapies, 18(3), 425-431.
  • Australian Dental Association. (n.d.). TMJ Disorder (TMD) Fact Sheet.